Summary: Spliceosome machinery mutations are common early mutations in myeloid malignancies; however, effective targeted therapies against them are still lacking.In the current study, we used an in vitro high-throughput drug screen among four different isogenic cell lines and identified RKI-1447, a Rho-associated protein kinase inhibitor, as select
Introduction Despite data documenting consistent and ongoing health disparities, health care professionals have yet to make significant change.Health care education Exam Lamps that thoughtfully prepares health care providers to address the social determinants of health and health inequities is a crucial step in improving health disparities.The deve
Introduction: Brain drain, an increasing phenomenon, Cosmetic Bag can be defined as the international transfer of resources, in the form of a highly educated workforce, from developing to more developed countries.The tendency for migration leads to the activation of informational behaviour.The aim of this study was to search for the main causes of
Background: In middle-income countries, costs limit widespred use of left ventricular assist device (LVAD) as a strategy for end-stage heart failure.We aim to describe the experience of a LVAD program in a middle-income country in a hub-and-spoke model.Methods: Patients fulfilling strict inclusion and exclusion criteria were referred from PONCHO di
Members of the Protein Tyrosine Phosphatase (PTPs) family are associated with growth regulation and cancer development.Acting as natural counterpart of tyrosine kinases (TKs), mainly involved in crucial signaling pathways such as regulation of cell cycle, proliferation, invasion and angiogenesis, they represent key parts of complex physiological ho